Prozac (Fluoxetine)
4.84 / 271

Prozac (Fluoxetine)

4.84 / 271

Prozac is used in the treatment of depression, obsessive-compulsive disorders, premenstrual disorders.

The drug is more commonly used to improve mood and reduce anxiety. It is the most preferred medicine for depressions complicated by lethargy, excessive sleepiness and weakness.

Due to its broad spectrum of action, Prozac is considered one of the most universal antidepressants.

Prozac Generic

Drug Info

  • Brand name: Prozac;
  • Active ingredient: Fluoxetine;
  • Manufacturer: Eli Lilly.

Prozac and its drug substance Fluoxetine

Fluoxetine, the active ingredient of Prozac, was discovered in 1972 by Eli Lilly and Company. It has been used in medicine since 1986. The drug is included in the World Health Organization list of essential medicines for the treatment of depression with motor retardation and increased drowsiness.

Prozac is an antidepressant that works by reuptake of serotonin.

Serotonin is an important brain neurotransmitter that helps regulate the sleep and wake cycles of the body and is responsible for mood and emotional stability.

The pharmacological action of Fluoxetine is aimed at increasing the level of serotonin in brain structures. This contributes to an increase in the duration of the stimulating effect of serotonin on the CNS and a decrease in the symptoms of depression.

Indications for use

All serotonin reuptake inhibitors, including Prozac, are most effective in depression and anxiety disorders.

Prozac is recommended for use with:

  • Depression;
  • Obsessive-compulsive disorder;
  • Bulimia nervosa;
  • Anxiety disorder;
  • Emergency treatment for panic disorder.

Prozac in combination with Olanzapine is prescribed for treatment of depression associated with bipolar I disorder.

Due to a wide range of pharmacological action, Fluoxetine can be used as prescribed by a doctor, in:

  • Premature ejaculation;
  • Migraine;
  • Diabetic neuropathy (a condition resulting from the lack of treatment or late detection of diabetes, which manifests in a degenerative lesion of all elements of the nervous system);
  • Fibromyalgia (a disease that causes pain in the muscles, ligaments, and tendons).

Prozac buying options

You can buy Prozac in two ways:

  • You can do it in a classic way, that is you can visit a doctor, get a prescription and buy the drug at a pharmacy;
  • You can order the drug online and have it delivered to your home.

The first option is more familiar to most people but is accompanied with additional expenses. You have to pay for a doctor’s consultation and buy Prozac at a higher price at a local drug store.

Buying Prozac online may seem new to you. But making an order at an online pharmacy is as easy as buying things or a laptop at any other online store.

  • You have no need to go to a doctor and get a prescription;
  • You save your time;
  • You can buy Prozac (Fluoxetine) online even if you lost your prescription or if it is expired;
  • You maintain complete confidentiality;
  • You can place an order 24/7;
  • The price of pills at an online pharmacy will be 3-4 times lower than at a city pharmacy.

Treatment regimens and dosages

Each diagnosis requires an individual approach to selection of a treatment regimen and dosage. So, if you decide to start taking this drug for the first time, you should consult your doctor and get individual recommendations.

Prozac dosage for bulimia nervosa:

Adult patients are prescribed 1 tablet of Prozac 60 mg once a day in the morning.

In the absence of contraindications, children are prescribed 10 mg (1 tablet) per day and, depending on the results, the dose can be increased to 20 mg or 40 mg.

Prozac dosage for depression:

The standard adult dosage is 1 tablet of Prozac 20 mg once a day in the morning. Dosage is adjusted as needed.

Children of 8 years of age and older are prescribed Prozac 10 mg or Prozac 20 mg once a day in the morning.

Prozac dosage for obsessive-compulsive disorder:

The starting dose is 20 mg once a day. The maximum daily dose is 80 mg (divided into 4 doses).

For children 7 of years of age, the starting dose of Prozac is 10 mg once a day in the morning. Children are not recommended to take more than 60 mg per day.

Prozac dosage for panic disorder:

The starting dose of Prozac for adults is 10 mg once a day in the morning.

Recommendations for use

The full therapeutic effect of Prozac is achieved within a few weeks of use. Most doctors prescribe Prozac for at least six months. For severe clinical depression, you can take Fluoxetine for more than 1 year, under the supervision of a healthcare professional.

You should begin your treatment with the lowest recommended dose. Every 2 weeks it is necessary to conduct an examination and evaluate the dynamics of therapy. In the absence of positive dynamics, the dose is increased.

It is not recommended to take more than 80 mg of Prozac per day, as this can provoke an overdose.

After achieving the result, the patient is transferred to a maintenance dose of 20 mg per day. The dose reduction usually lasts 4 weeks, but the doctor may suggest to decrease the dose gradually over 6–8 weeks to lower the risk of withdrawal syndrome.

Missed dose

If you sometimes forget to take the medication, don't worry. Take the next dose of the drug the following day at the usual time. Don't take the medicine twice a day to make up for a missed dose.



There are a number of chronic diseases, in which taking Prozac (Fluoxetine) is contraindicated:

  • Liver cirrhosis;
  • Problems with urination;
  • Diabetes;
  • Kidney failure;
  • Severe cardiovascular diseases;
  • Glaucoma;
  • Seizures or epilepsy;
  • Bipolar disorder (manic depression);
  • Drug abuse or suicidal behavior.

According to studies, in elderly patients Prozac can cause hyponatremia (fluid retention in the body, which leads to a sharp decrease in the volume of blood sodium to the critical level, below 135 mmol/l).

In turn, this can cause swelling, nausea, and other dangerous side effects. For this reason, elderly patients may require dose adjustment and special monitoring by a doctor. If swelling occurs, stop taking the tablets.

Use of Prozac during pregnancy

If you get pregnant while taking Prozac, tell your doctor. Taking Fluoxetine may be related with an increased risk for the development of fetus. So, you should stop taking the drug.

During clinical studies, it has been found out that Fluoxetine excretes with breast milk. For this reason, when taking the drug during lactation, it is necessary to transfer the child to artificial feeding.

Possible side effects

Fluoxetine is one of the safest antidepressants in modern medical practice. It rarely causes side effects due to selective action. In spite of this, in rare cases, patients experience unwanted symptoms.

The list of common side effects while taking Prozac include:

  • Insomnia or vice versa drowsiness;
  • Headache and dizziness;
  • Anxiety or nervousness, fatigue;
  • Dizziness or clouded consciousness;
  • Stomach upset, appetite loss, nausea, vomiting, diarrhea;
  • Dry mouth, sweating;
  • Weight or appetite change;

Most often, mild side effects do not require medical assistance. But if they bother you, consult a healthcare professional.

Prozac: interaction with other drugs

Prozac may cause blood thinning or bruising when taken with non-steroidal anti-inflammatory drugs, such as:

  • Aspirin;
  • Ibuprofen;
  • Naproxen;
  • Celebrex;
  • Diclofenac and other medicines.

You may need to adjust your Fluoxetine dosage, if you take medicines from the enlisted drug groups:

  • Drugs for treatment of attention deficit hyperactivity disorder;
  • Drugs for treatment of mental disorders and diseases;
  • Drugs for treatment of narcolepsy;
  • Drugs for headache and migraine;
  • Narcotic painkillers.

You should not use Prozac if you take antipsychotic drugs, such as Pimozide or Thioridazine.


Store out of the reach of children at a temperature from +15 °C to +30 °С.

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  • Mell Gilliam

    I have major depressive disorder, PTSD and a ton of anxieties. I’ve been on painkillers all my life. Unfortunately, now I have to add Prozac to the list. Well, as long as it keeps me away from certain thoughts, I can live with that. In addition, I am able to work, although I do experience lack of concentration when I’m on it.

  • Tyler Price

    This medication did not have an immediate effect on me. I suffer from PTSD and have troubles sleeping. I nearly quit the meds after several days, but my doctor advised me to stay on it a little longer. It just makes me tired and dizzy. I guess it does help a bit to calm me down, but not as much as I expected.

  • Oliver Davis

    Prozac has helped me to get rid of depression in just 2 weeks. Initially I was prescribed a 3 months course, but I’ve chosen to stop earlier. It was a little expensive, plus I feel much better.

  • William Short

    I never allowed myself to think that depression was an actual medical disorder. I thought it was mostly about advertising and profit. But a situation has occurred in my life, when my health was on the line. Antidepressants were instrumental in my recovery, and I am glad my mind was changed towards it, otherwise I would simply not make it out. I took Prozac on a daily basis following a facial reconstruction surgery.

  • Morgan Woods

    I’ve been having mild anxieties all my life. Recently, my nervousness went through the roof! What I thought was a positive change turned out to be a whole new load of responsibilities. It only took one week before I lost all my inspiration. This job opportunity, I was so after, was simply draining me. People that hired me, went from praise to smirk, and it was a finishing blow for me. There was a lot on the line, and it nearly finished me off. I’ve never used any psychoactive meds before and was kinda hoping to stay away from it altogether. This time, however, I had to crawl out of the hole, and it was Prozac that helped me.

  • Danni Hawkins

    I am on week 3 of Prozac. It saved me from doing something terrible to myself, and it has shown me that there is still reason to live. I gave up on myself because of betrayal by someone I felt very attached to. But I was wrong! There is much more to life than sorrow and ridiculous attachment to someone who doesn’t care. I rediscovered things I loved doing when I was a teenager. All I needed was a little break from the anguish, and it has done a miracle.

  • Rachel Hopkins

    Hi! I am 50, and I’ve been on various SSRI meds for over 7 years. From my experience, Prozac has been the most effective. Its effects are much more obvious, and it starts to work faster than other meds I have tried.

  • Zak Chapman

    Hello! I was taking Prozac for sometime last year. It did help me with the depression, but I noticed that I started to forget things and basically became very disorganized. I kept losing my keys and forgetting where I put things. That made me feel angry at times, and I decided to stop taking meds altogether. Perhaps, I would resume the therapy if my condition gets out of control.

  • Layton George

    I was taking Prozac in small doses while in school, since I am very prone to panic attacks. I have tried other antidepressants/stimulants, but Prozac was the most effective in my case.

  • Sebastian Harper

    Hi! I’ve been recovering from COVID several weeks ago. For some reason, it mostly affected my mental health. There were flu-like symptoms, of course, but this time it has also given me a constant hyped-up feeling of alarm. For no reason at all, my heart was racing all the time. I had a difficult time falling asleep. I am still taking Prozac daily, and it helps to deal with the discomfort.

  • Andrew Lawerence

    I highly recommend Prozac for all mental disorders. I have seen it working for my friends, and I am very grateful that these people are still alive and well thanks to this drug. There are side effects, but as long as it is used as intended, the side effects are minimized.

  • Rene Davidson

    Hi, I’ve been living with OCD since childhood, and also I am very awkward around people. The funny thing about Prozac is that it makes OCD seem fun, and it does not torment me as much.

  • Iren Booth

    I do not have depression or anything like that. My doctor prescribed Prozac to treat menstrual pains. Painkillers do not work for me for some reason. Without it, for several days every month, I would be completely out of commission.

  • Patrick Gray

    I worry extensively. It is my job, actually, to worry. I manage a large group of people. I worry professionally, one might say. But it has become a habit I intend to suppress, especially nearing my retirement. I recommend Prozac to anyone who has dreadful thoughts and need to take a break from stressful work.

  • Angus Newman

    I am taking Prozac to help with PTSD. I have some harsh memories that constantly flash in my mind unexpectedly. I must admit that Prozac does not erase or take away memories or suffering from the past, but it does make it seem far less important.

  • Amelie Green

    I am suffering from intrusive thoughts and various other forms of mental health issues. I have been on Prozac for 3 years. The side effects for me are dizziness, dry mouth and sometimes a headache. Headaches, I’ve found, were easily managed by drinking lots of fluids.

  • Molly Tanner

    I am 55 years old female with an extensive medical history. Prozac has been recommended by our family doctor, and it is the only antidepressant that I trust.

  • Emil Dupuy

    But apparently, I messed up the chemical balance in my brain. I am constantly playing video games and would neglect my sleep cycles year after year. It has got to the stage when I would burst with anger over the smallest things. Had a psychotherapy session for the first time in my 29 years of age. I was prescribed Prozac for 2 months. It took me a while to get used to the schedule, but it definitely saved me from something terrible, to say the least.

  • Christian Harvey

    I’ve always considered anxiety to be rather whims of one’s mind rather than a medical condition.

  • Mariam Moore

    Hi! I’ve had a severe depression for years. I’ve tried many things, and I’ve figured out that staying active worked the best. But I can not dedicate too much of my energy just for exercise. Prozac became my alternative solution, especially throughout busy seasons at work, when I can not afford to be away from my desk.

  • Julia Coleman

    I was afraid to take antidepressants, because I read a lot about side effects. But I was getting really tense and something needed to be done. I had to spend a lot of time to find a good psychotherapist. The doctor explained everything in detail and showed me that antidepressants are safe if taken properly. We decided to go with Prozac, because it was the most popular medication within the antidepressant category. I’ve had a 5 months therapy course, and it helped me to stay focused. When I came out of it, there were no side effects whatsoever

  • Mason Phillips

    Hello! I was prescribed Prozac to help me with panic and depression after I have had surgery. I am terrified of hospitals in general, and medical procedures make me feel insane. Long story short, I still had nightmares and feelings of discomfort. I would boil up with awful fear every night, I fell asleep only when I was completely exhausted. I have to say, Prozac started a shift towards positive feelings and perception of my life. Moreover, the positive effects remained with me even after I had finished the treatment course.

  • Megan Powell

    Hey! I am on Prozac for one week. The doctor gave it to me for anxiety. And it works great!

  • Louis Brooks

    I take Prozac regularly. I hardly imagine myself functioning without it. It helps me to stay normal when I talk to people. At first, I’d worry that it zombifies me in some ways. I would feel dizzy and less active. But then I came to appreciate the feeling of calm. Basically, it makes me feel less jittery.

  • Brian Roy

    Prozac is well known to me, and I have used it several times in my life. The important thing to realize is that it does not take away all life’s problems, but it does help when you are going through some exceptionally emotional challenges.

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