Nolvadex (Tamoxifen)

Drug Info

• Brand Names: Nolvadex, Tamoxican, Tamilong;
• Active Ingredient: Tamoxifen Citrate;
• Manufacturer: AstraZeneca.

Nolvadex and its active substance Tamoxifen

The active ingredient of Nolvadex is Tamoxifen. It is an estrogen antagonist, also having a selective stimulating effect on estrogen receptors. In the cells of the mammary gland, it plays the role of an anti-estrogen, and in the cells of other tissues (bones, uterus), Tamoxifen acts as an estrogen.

The effect of the drug depends on the purpose of its use. Tamoxifen suppresses tumor growth when used to treat breast cancer. After you take the pill, the drug substance gets into the blood and blocks estrogen receptors in the mammary gland, preventing estrogen from reaching cancer cells.

Indications for use

Nolvadex is mainly used for the treatment of estrogen-dependent diseases. The main indications for using the drug are as follows:

• Breast cancer;
• Primary prevention of breast cancer in women at high and moderate risk;
• Anovulatory infertility.

Using Nolvadex in bodybuilding is common to reduce estrogen and prevent gynecomastia in men.

Treatment regimens and dosages

The drug is available in dosages of 10 mg and 20 mg. Depending on the disease and individual characteristics, the doctor prescribes a dosage and treatment regimen. The following dosages and treatment regimens are usually used:

• For breast cancer, the standard recommended daily dosage is Nolvadex 20 mg. The doctor determines the treatment duration based on the disease's severity and other factors.
• Nolvadex 20 mg is also used for the primary prevention of breast cancer, with a treatment duration of about 5 years.
• For anovulatory infertility, the starting dose is Nolvadex 20 mg on the cycle's second, third, fourth, and fifth days. Then, you can increase the daily dosage to 40 mg if required.

You can take the drug once or twice a day. The doctor may decrease or increase the daily dosage if appropriate. Follow the doctor's recommendations, and don't change the dosage on your own.

Older people can use the same dosages, as there is no evidence that their response to Tamoxifen differs from that of younger people.

Nolvadex may affect thyroid function test results. So, inform them about taking the drug before the test.

Recommendations for use

Nolvadex is available as an oral tablets. To get the maximum effect from the medication, follow these rules:

• Take the drug at the same time;
• Don't crush the pill before use;
• Take the tablet with plenty of water;
• If you take several tablets at a time, take each of them with water.
• Take the drug before or after meals.

During treatment, you should minimize or stop drinking alcohol, as it may increase the side effects of Tamoxifen and reduce the effectiveness of treatment. If you can't completely give up alcohol, ask the doctor to determine your acceptable limit.

Grapefruits (and grapefruit juice) and tangerines can also lower the effectiveness of the medicine.

Missed Dose

Follow the treatment regimen, and don't miss doses. If you miss a dose, your next action depends on how many times a day you take the drug:

• If you take the medication once a day and if less than 12 hours have passed since the last dose, take the prescribed single dose of Nolvadex. If more than 12 hours have passed, skip the dose and wait until your next dose.
• If you take the drug twice a day, take the missed dose as soon as you remember. If it is near time for your next dose, take only that dose. Then, return to your regular Nolvadex treatment regimen. Don't take a double or extra dose.

Precautions

Before treatment, inform the doctor about all your diseases. In some cases, a doctor should control the treatment. These cases include:

• Drug allergies;
• Deep vein thrombosis;
• Pulmonary embolism;
• Heart stroke;
• High cholesterol;
• Diabetes;
• Hypertension;
• Cataract;
• Liver disease.

Individual intolerance, pregnancy, and breastfeeding are among the medicine contraindications.

Use of Nolvadex during pregnancy

Pregnant women shouldn't use the drug due to the high risk to the fetus. Moreover, during treatment, you should avoid pregnancy using proven contraception methods. If you get pregnant while using Nolvadex, stop taking the drug immediately and inform the doctor.

Currently, there is no data on whether Tamoxifen gets into breast milk. So, due to the possible risk to the child, you shouldn't also use the drug during breastfeeding.

Nolvadex in bodybuilding

In bodybuilding, Nolvadex PCT (Post Cycle Therapy) is an effective way to avoid the effects of steroids. The drug also helps reduce estrogen levels and improve training results.

You can also use Nolvadex for gyno (gynecomastia) in men. Anabolic steroids may cause gynecomastia. So, after taking these drugs, you can use Nolvadex to prevent this medical condition. Using Nolvadex in bodybuilding has these benefits:

• Restoring hormonal levels;
• Preventing gynecomastia;
• Preventing other side effects of steroid drugs;
• Improving skin and hair condition;
• Decreasing blood pressure;
• Reducing cholesterol.

Possible Nolvadex side effects

Usually, people tolerate the drug well, and possible side effects are mild and go away with time. The most common side effects are as follows:

• Headache;
• Nausea;
• Leg cramps;
• Flushes of blood to the face;
• Hair thinning;
• Muscle pain.

You may rarely have severe side effects, such as:

• Blurred vision or other eyesight changes;
• Pain in the eyes;
• Bruising or bleeding;
• Nausea, vomiting, loss of appetite, yellow whites of the eyes;
• Severe allergic reactions (difficulty breathing, rash, swelling).

If side effects increase or you experience severe side effects during treatment, see the doctor immediately.

Nolvadex: interaction with other drugs

Nolvadex may interact with other medications. So, before treatment, inform the doctor about all the medicines you take. Adverse effects are possible when combining it with these drugs:

• Anticoagulants or blood thinners;
• Estrogen-containing drugs;
• Hormonal contraceptives;
• SSRI antidepressants;
• Anticonvulsants;
• St. John's wort-based drugs.

It is not a complete list of drug interactions. For more information about possible interactions, check with a doctor or pharmacist and read the package insert for the drug.

Storage

Store Nolvadex at room temperature 20 - 25°С in a dark place out of the reach of children and animals. Don't use the drug if the expiration date has passed or the packaging is damaged.

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