Accutane (Isotretinoin)
4.83 / 359

Accutane (Isotretinoin)

4.83 / 359

Accutane is a pharmaceutical drug from the group of retinoids. System monotherapy with Accutane is the most effective treatment for the most severe forms of acne that do not respond to cosmetic skin care products and antibiotics.

Accutane also shows high efficacy in the treatment of seborrhea and perioral dermatitis. According to the results of clinical studies, its effectiveness is 96.4% in the treatment of moderate to severe acne. Moreover, the disease came back to patients within 5 years in less than 8% of cases.

Accutane Generic

Drug Info

  • Brand Name: Accutane;
  • Active Ingredient: Isotretinoin;
  • Manufacturer: Roche.

Active substance Isotretinoin

Isotretinoin is the main active ingredient of Accutane tablets. It treats acne by reducing sebum production and slowing down cell division of sebaceous glands.

In case of increased reproduction of these cells, sebaceous glands get clogged. As a result, the evacuation of sebum is disrupted. An infectious process begins within the glands, and acne develops.

  • Isotretinoin not only helps to reduce the production of sebum, but also changes its structure. Sebum gets softer and is easily removed from the gland ducts.
  • Thanks to the improvement of the sebum flow, the inflammatory process on the skin reduces. Usually, the process is a result of the active reproduction of bacteria in the clogged ducts.
  • Regenerative processes in the dermis improve. This allows to quickly restore the skin after inflammatory processes while reducing the risk of scarring.

Indications for use

Severe forms of acne that do not respond to conventional cosmetic skin care products are the following:

  • Acne conglobata;
  • Nodular and cystic acne;
  • Acne with a risk of cyst formation;
  • Rosacea.

Accutane is also used to reduce the likelihood of scarring after acne, remove dark spots and improve skin texture for account of skin regeneration.

Treatment regimens and dosages

Accutane is available online in oral tablets: 5 mg, 10 mg, 20 mg, 30 mg and 40 mg.

Tablets/capsules are taken during meals 2 times a day. A daily dose is divided into 2 parts to reduce the risk of side effects from the part of the gastrointestinal tract. A dose is selected individually. It depends on the severity of the disease and the patient’s health condition, contraindications and body weight.

  • Treatment is started with a minimum dose of 0.4-0.5 mg per 1 kg of body weight per day (if the body weight is 80 kg, the daily dose is 40 mg, which is 1 tablet of Accutane 20 mg twice a day).
  • The dose is gradually increased up to 2 mg/kg of body weight in case of damage to the back, neck and chest, or severe course of the disease (if the body weight is 60 kg, the daily dose is 120 mg). In this case, a daily dose can be divided into 3 equal parts, which is 1 tablet of Accutane 40 mg 3 times a day, with an interval of 8 hours.

There is no sense in taking more than 2 mg per 1 kg of body weight. This is the maximum safe dose that does not cause severe side effects and provides the maximum result.

Recommendations for use

  • Treatment lasts at least 12 weeks.
  • The optimal period for using Accutane is 24 weeks. If the overall clinical picture has improved by more than 80% during this period, treatment is stopped.
  • If the results do not satisfy the doctor or the patient after 24 weeks, the treatment is continued. The second treatment course is started after a certain period of time. The period is at least 3 months.
  • The drugs must be taken with plenty of water.
  • While taking the pills, you should limit exposure to sunlight and ultraviolet rays. Use a cream with a high sun protection factor (at least SPF 30).

Missed Dose

During the day, it is important to follow the prescribed treatment and dosage regimens. If you forget to take a daily dose, continue the regimen without making up for the missed dose by increasing the amount of Accutane in the following days.


This drug is not prescribed to patients with severe liver disorders. The use of Accutane increases the load on the liver, which may cause complications.

Also, you should not take Accutane, if you suffer from:

  • Hypervitaminosis A;
  • Depression;
  • A significant increase in blood sugar levels;
  • Lipid metabolism disorders.

Accutane is prescribed to persons over 12 years of age.

Use of Accutane during pregnancy

It is strictly contraindicated to use Accutane during pregnancy. It has a teratogenic effect and can cause congenital malformations in the fetus. Also, you should not take the drug, if you are breastfeeding.

Possible side effects

Despite its high effectiveness, the use of Isotretinoin may be limited by the range of possible side effects. According to clinical studies, the use of Accutane can cause the following side effects:

  • Inflammatory bowel disease;
  • Dry skin, dermatitis;
  • Headache;
  • Symptoms of depression.

Allergic skin reactions such as redness and itching are possible. In case of these allergic reactions, regardless of their localization and severity, you should consult with a doctor.

Isotretinoin: interaction with other drugs

  • Isotretinoin may decrease the effect of oral hormonal contraceptives;
  • When taken with tetracyclines, Accutane increases the side effects of antibiotics, in particular, increased intracranial pressure.
  • During the treatment with Isotretinoin, do not use alcohol-containing drugs or alcohol.


Store Accutane in a dry, dark place at a temperature not exceeding 20°С out of the reach of children.

Buy Accutane with delivery within Europe

If you want to buy Accutane at a low price, you can place an order at our online pharmacy. You will get a high-quality service, qualified consultation from medical experts, original Accutane and fast delivery to any country of Europe.

The specific of our service is that we supply only original Accutane online from the manufacturer. The storehouses in Europe and an established logistics system ensure prompt delivery to any city within the EU.

You can buy Accutane without a prescription, provided that you are over 18 years old. But we do not recommend to use the drug without consulting a specialist, as improper use of the pills can harm your body.

  • Anton Huddleston

    At 17, I had oily skin, severe acne, low self-esteem, and was depressed and anti-social. I decided to try Accutane and I'm VERY HAPPY I DID IT! Terrible acne disappeared, the skin is no longer oily. My self-esteem is 1000000 times higher than before.

  • Ellery Rogerson

    I 100% recommend this drug! At 21, I had severe acne. At first, I used antibiotics, they helped by 75%. Accutane completely cleared my skin, although not right away. My worst side effects were back pain and flaky skin. They disappeared after about a month of treatment. Now I'm 23, and I have great skin.

  • Gillian Fay

    The pills for pimples work great, they have changed my life and self-esteem.

  • Damian Elmer

    This is my first Accutane treatment and it's coming to an end. I had no problems with taking the pills, only a positive effect on the skin.

  • Mattis Fontaine

    I'm 22, and I've been taking these pills for about 3 months now. So far so good, no serious side effects other than dry skin and slight muscle fatigue. Now my skin is not perfect, but the difference is huge. I'm not as shy as I used to be. I'm very glad I switched to this medication.

  • Hamilton Moses

    The order came quickly in good packaging. I'll buy Accutane here again.

  • Isidore Lama

    I highly recommend Accutane, but it's best to consult a dermatologist first. Acne treatment takes a lot of time and effort, so be patient!

  • Dwayne Butts

    I was told that this is a good medicine and I decided to try it. The results were wonderful! To be honest, if you have severe acne, this product is probably the best option for you. It has side effects, like any drug.

  • Omar Giehl

    Of course, there are many good medicines and cosmetics for acne. Everyone has different experience with acne. As for me, Accutane helped me a lot and there were no side effects.

  • Maurice Cummins

    I bought Accutane online, happy with everything. Fantastic service.

  • Sterling Parkins

    Hello to everyone. A dermatologist prescribed Accutane and I took pills for 6 months. After many years of fighting pimples, the skin began to shine with health. To be honest, none of the drugs have worked as well as Accutane.

  • Cara Readdie

    I sincerely think that if I had taken Accutane before, my life might have been different. Now I'm proud of my acne-free skin.

  • Laurel Paige

    Accutane use was an experience that changed my life. The treatment was long, with many side effects, but in the end it was worth it. I finally feel attractive.

  • Mariano Stueck

    I've probably tried every acne medication and also passed a detox course to clear the toxins out of my body. Accutane is an amazing drug. When I looked in the mirror earlier, I felt pain, now I would look in the mirror for hours.

  • Fedele Gauthier

    The medicine works great! I get compliments all the time from people who knew me.

  • Hubert Walter

    Hello, I have ordered Accutane for the fifth time. I like this pharmacy, they work fast and I always get what I need.

  • Kasey Apted

    I had very deep pimples. In the autumn of 2021, I started a course of Accutane taking 80 mg. The doctor at once said that acne treatment takes time. As for results, I had quite a long skin clearing period, but that's in the past now. I am very grateful to Accutane, my skin has never been so clear!

  • Shanon Victors

    I ordered Accutane for 2 months. Excellent service that has never failed.

  • Heather Merrill

    I have had acne for about four years and have tried many medications to treat it. On the recommendation of a dermatologist, I switched to these pills three months ago. Pimples are not completely gone, there are still reddish spots under the skin that I think will disappear with time. There are few side effects and they are not very annoying. I hope my skin gets better in a couple of months.

  • Estelle May

    I'm very satisfied with the end result. Acne has gone and never returned.

  • Nikole Bennett

    Pimples drove me crazy. I tried many creams and pills, but all was in vain. My dermatologist recommended a 5-month Accutane treatment for me. Pimples completely disappeared, the skin began to look rejuvenated. I am very satisfied with the treatment.

  • Logan Stacks

    Always keep mint candies and fruit drops at hand. As for me, they helped me a lot to deal with nausea in the first week.

  • Earl Case

    Yes, Accutane causes side effects, but not everything is as bad as it seems. If you know another 100 % method to get rid of acne, write about it.

  • Morgan Bisset

    I ordered Accutane online at a very good price. Fast delivery and very convenient website for shopping.

  • Kirby Backus

    I began to take Accutane because I don't want to have scars on my skin as my friend does.

  • Quintin Howse

    I was very afraid of the side effects of Accutane, but apart from dry skin and dry mouth, I did not experience anything. The side effects are unpleasant, but it's a small price to pay for clear skin. There is nothing worse than acne.

  • Arabella Smedley

    My ONLY regret is that I didn't use Accutane before.

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